Lrdm1^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Lrdm1^MRL/MpJ
• Name: lymphoproliferation (Fas) renal disease modifier 1; MRL/MpJ
• MGI ID: MGI:2156890
• QTL: Lrdm1 Location: Chr7:3352048-24879418 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased nephritis compared to CAST/Ei. (J:3304)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:3304

Over 110 (MRL/MpJ-Tnfrsf6^lpr/J x CAST/Ei)F1 x MRL/MpJ-Tnfrsf6^lpr/J backcross animals were typed at 108 polymorphic loci to identify QTLs associated with nephritis. Parental strain MRL/MpJ-Tnfrsf6^lpr/J exhibits severe autoimmune nephritis compared to parental strain CAST/Ei.

A locus named Lrdm1 mapped to approximately 6 cM on mouse Chromosome 7 between Pou2f2 (2 cM) and Prkcc (6 cM). MRL/MpJ-derived alleles are associated with nephritis at Lrdm1.

A second locus mapped to approximately 35 cM on mouse Chromosome 12 between D12Nyu3 (27 cM) and D12Sel1 (43 cM). MRL/MpJ-derived alleles are associated with nephritis at Lrdm2.

References

• Original: J:3304 Watson ML, et al., Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med. 1992 Dec 1;176(6):1645-56
• All: 1 reference(s)