Hcs1^C3H/He
QTL Variant Detail

Summary

• QTL variant: Hcs1^C3H/He
• Name: hepatocarcinogenesis susceptibility 1; C3H/He
• MGI ID: MGI:2156892
• QTL: Hcs1 Location: Chr7:74326121-74326352 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 43.46 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/He

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to hepatocarcinogenesis compared to A/J. (J:3657)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:3657

Quantitative trait locus analysis (QTL) was used to determine that a locus on mouse Chromosome 7 was associated with liver tumor development in the F2 generation in male A/J x C3H/He mice. There were 174 informative meioses. This locus designated Hsc1 shows a significant association with D7Nds1 and is localized 2 cM distal to Mtv1.

References

• Original: J:3657 Gariboldi M, et al., Chromosome mapping of murine susceptibility loci to liver carcinogenesis. Cancer Res. 1993 Jan 15;53(2):209-11
• All: 1 reference(s)