Cfd^tm1Yxu
Targeted Allele Detail

Summary

• Symbol: Cfd^tm1Yxu
• Name: complement factor D; targeted mutation 1, Yuanyuan Xu
• MGI ID: MGI:2156994
• Synonyms: Df-, factor D^-, fD-, fD KO
• Gene: Cfd Location: Chr10:79726687-79728489 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Cfd^tm1Yxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73125
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon 3, which encodes the Asp residue of the serine protease active center, disrupted the gene. Northern blot analyses of fat, muscle, lung, and liver did not detect message in homozygous mutant mice. Western blot analysis did not detect protein in homozygous mutant mouse sera. (J:73125)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfd Mutation: 21 strains or lines available

References

• Original: J:73125 Xu Y, et al., Complement activation in factor D-deficient mice. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14577-82
• All: 27 reference(s)