Eae24^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae24^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 24; SJL/J
• MGI ID: MGI:2157011
• QTL: Eae24 Location: Chr8:25103201-25103372 bp Genetic Position: Chr8, cM position of peak correlated region/allele: 12.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67793

298 (SJL/J x B10.S)F1 x B10.S backcross animals were typed for microsatellite markers at an average spacing of 15 cM to identify QTLs associated with experimentally induced allergic encephalomyelitis (EAE) sub-phenotypes. Inbred strain SJL/J is EAE susceptible while B10.S is EAE resistant. This study revealed new phenotypes in association with previously identified QTLs: Eae8 on mouse Chromosome 2 segregates with EAE-related weight loss (P = 6.7 x 10^-5 at D2Mit200) and Eae3 on mouse chromosome 3 segregates with paralysis (P = 1.4 x 10^-3 at D3Mit40). A new locus, Eae24, mapped to mouse Chromosome 8 in association with inflammation and paralysis (P = 8.2 x 10^{-6 at D8Mit3). Possible candidate genes for Eae24 are scat (severe combined anemia and thrombocytopenia), mnd (motor neuron degeneration) and Plcd (phospholipase C, delta). A suggestive locus for paralysis and mapped to mouse Chromosome 18 near 55 cM (P = 1.9 x 10<-3} at D18Nds1).

References

• Original: J:67793 Encinas JA, et al., Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar;13(3):257-64
• All: 1 reference(s)