Rasgrf1^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Rasgrf1^tm1Kln
• Name: RAS protein-specific guanine nucleotide-releasing factor 1; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:2157015
• Synonyms: Ras-GRF -, Ras-GRF1-KO
• Gene: Rasgrf1 Location: Chr9:89791961-89909030 bp, + strand Genetic Position: Chr9, 47.31 cM
• Alliance: Rasgrf1^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73879
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 3-5 was replaced with a neomycin selection cassette. This region encodes the exchange-factor catalytic domain. Western blot analysis on brain extracts of homozygous mice indicated that no detectable protein was produced from this allele. (J:73879)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rasgrf1 Mutation: 66 strains or lines available

References

• Original: J:73879 Brambilla R, et al., A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature. 1997 Nov 20;390(6657):281-6
• All: 10 reference(s)