Tg(Ins2-IAPP)RHFSoel
Transgene Detail

Summary

• Symbol: Tg(Ins2-IAPP)RHFSoel
• Name: transgene insertion RHF, Walter C Soeller
• MGI ID: MGI:2157065
• Synonyms: RIPHAT, RIPHAT line RHF, Tg(IAPP)6Jdm
• Transgene: Tg(Ins2-IAPP)RHFSoel Location: unknown
• Alliance: Tg(Ins2-IAPP)RHFSoel page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-IAPP)RHFSoel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IAPP (3375)

  Iapp	(MGI:96382)

• Tg(Ins2-IAPP)RHFSoel expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The transgene consisted of cDNA encompassing the Human IAPP coding sequence under the regulation of the rat insulin II promoter (Ins2). (J:73886)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:73886 Couce M, et al., Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction. Diabetes. 1996 Aug;45(8):1094-101
• All: 38 reference(s)