Hcs3^A/J
QTL Variant Detail

Summary

• QTL variant: Hcs3^A/J
• Name: hepatocarcinogenesis susceptibility 3; A/J
• MGI ID: MGI:2157086
• QTL: Hcs3 Location: unknown Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to hepatocarcinogenesis compared to C3H/HeJ. (J:3657)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:3657

Quantitative trait locus analysis (QTL) was used to determine that a locus on mouse Chromosome 12 was associated with liver tumor development in the F2 generation in male A/J x C3H/He mice. There were 174 informative meioses. This locus designated Hsc3 shows a significant association with telomeric markers Odc-rs8 and Igh-V.

References

• Original: J:3657 Gariboldi M, et al., Chromosome mapping of murine susceptibility loci to liver carcinogenesis. Cancer Res. 1993 Jan 15;53(2):209-11
• All: 1 reference(s)