Apob^tm1Bres
Targeted Allele Detail

Summary

• Symbol: Apob^tm1Bres
• Name: apolipoprotein B; targeted mutation 1, Jan L Breslow
• MGI ID: MGI:2157090
• Gene: Apob Location: Chr12:8027648-8066835 bp, + strand Genetic Position: Chr12, 3.53 cM
• Alliance: Apob^tm1Bres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29700
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A genomic fragment containing exons 1-3 was replaced with a neomycin selection cassette. (J:29700)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apob Mutation: 224 strains or lines available

References

• Original: J:29700 Huang LS, et al., apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest. 1995 Nov;96(5):2152-61
• All: 2 reference(s)