Im2^Bioz:BP1
QTL Variant Detail

Summary

• QTL variant: Im2^Bioz:BP1
• Name: immunoregulatory 2; Bioz:BP1
• MGI ID: MGI:2157092
• Synonyms: high antibody responder, Im2^H
• QTL: Im2 Location: Chr4:45077682-45077816 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 52.81 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: Bioz:BP1

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased antibody response compared to Bioz:BP1. (J:65671)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:65671

Im2 (immunoregulatory 2), a QTL on mouse chromosome 4 affecting antibody response, was one of several immunoregulatory loci mapped in 1996 by Puel et al (J:37521). Interval specific congenic strains (ISCS) were constructed for each immunoregulatory QTL on mouse Chromosome 4, 6, 8, 10, 12, and 18. Animals from a high (H) antibody responder line were successively backcrossed to the low (L) antibody responder line to fix H-derived alleles for each QTL on an L-derived background. Each ISCS line was challenged with i.v. injection of anti-CD3 mAb and analyzed for IL4 response. The ISCS line carrying Im2, the H-derived Chromosome 4 QTL spanning 51 cM - 59 cM, retained a significant high responder phenotype (P<0.05), thus confirming the locus. Candidate genes inthe region of Im2 include Tnfsf8 (Cd301), Jak1, Bmfr1, Il14, Csf3r, Idd11, and Ifna. Sle2 is a QTL associated with autoimmune disease in the region of Im2.

J:37251

High(H) and Low(L) antibody responder lines of Biozzi mice were used in mapping Im loci. (H x L)F1 x L mice were informative in mapping Im2 with D4Mit5.

References

• Original: J:65671 Araujo LM, et al., NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes. Int Immunol. 2000 Nov;12(11):1613-22
• All: 2 reference(s)