Derm1^NC/Nga
QTL Variant Detail

Summary

• QTL variant: Derm1^NC/Nga
• Name: dermatitis 1; NC/Nga
• MGI ID: MGI:2157106
• QTL: Derm1 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 33.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NC/Nga

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to atopic dermatitis (AD) compared to MSM/Ms. (J:68698)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68698

Mouse strain NC/Nga is a model for human dermatitis. In an effort to map the gene or genes responsible for dermatitis in mice a genome wide scan was employed using 93 segregrants from a (NC/Nga x MSM/MS)F1 x NC backcross. Only backcross mice which exhibited severe dermatitis, were informative. A dermatitis locus (derm) significantly (chi square 16.4) segregated with markers D9Mit163, D9Mit72, D9Mit143, D9Mit103, D9Mit207 and D9Mit209 on mouse Chromosome 9. The authors suggest that Csk could be a candidate for the dermatitis phenotype in the NC/Nga strain. Authors used Derm1 for Derm.

References

• Original: J:68698 Kohara Y, et al., A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics. 2001 Feb;53(1):15-21
• All: 5 reference(s)