Apoa2^tm1Bres
Targeted Allele Detail

Summary

• Symbol: Apoa2^tm1Bres
• Name: apolipoprotein A-II; targeted mutation 1, Jan L Breslow
• MGI ID: MGI:2157148
• Synonyms: apoA-II -
• Gene: Apoa2 Location: Chr1:171052623-171053948 bp, + strand Genetic Position: Chr1, 79.22 cM
• Alliance: Apoa2^tm1Bres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37250
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 1-3 and part of exon 4 was replaced with a neomycin selection cassette. Northern blot analysis on total liver RNA demonstrated that the transcript was not detectable in homozygous mice, and the encoded protein was not detected in HDL isolates of plasma derived from homozygous mice. (J:37250)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Apoa2 Mutation: 20 strains or lines available

References

• Original: J:37250 Weng W, et al., Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14788-94
• All: 9 reference(s)