Apoa4^tm1Bres
Targeted Allele Detail

Summary

• Symbol: Apoa4^tm1Bres
• Name: apolipoprotein A-IV; targeted mutation 1, Jan L Breslow
• MGI ID: MGI:2157162
• Synonyms: apoA-IV -
• Gene: Apoa4 Location: Chr9:46152142-46154756 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Apoa4^tm1Bres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43015
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.1kb genomic fragment containing exon 1 and intron 1 was replaced with a neomycin selection cassette. No transcript was detectable in northern blot analysis on intestinal RNA from homozygous mice, and western blot analysis demonstrated that no stable protein was detectable in plasma of homozygous mice. (J:43015)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoa4 Mutation: 22 strains or lines available

References

• Original: J:43015 Weinstock PH, et al., Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res. 1997 Sep;38(9):1782-94
• All: 21 reference(s)