Apobec1^tm1Ddsn
Targeted Allele Detail

Summary

• Symbol: Apobec1^tm1Ddsn
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; targeted mutation 1, Nicholas O Davidson
• MGI ID: MGI:2157186
• Synonyms: apoB100^-, apobec-1-, apobec-1 KO
• Gene: Apobec1 Location: Chr6:122554751-122579403 bp, - strand Genetic Position: Chr6, 57.68 cM
• Alliance: Apobec1^tm1Ddsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32731
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 6, encoding the zinc finger and catalytic glutamate, was replaced with a neomycin selection cassette. No transcript was detectable in RNAse protection assays on RNA isolated from liver and small intestine of homozygous mice. (J:32731)

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apobec1 Mutation: 28 strains or lines available

References

• Original: J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
• All: 33 reference(s)