Pid2^CAST/Ei
QTL Variant Detail

Summary

• QTL variant: Pid2^CAST/Ei
• Name: prion incubation determinant 2; CAST/Ei
• MGI ID: MGI:2157199
• QTL: Pid2 Location: Chr9:37153362-44251323 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 20.74 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased prion incubation time.
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Pid2 is consistent with a recessive or additive mode of inheritance. Pid2 and Pid3 interact additively.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:65122

Prion ( Scrapie) incubation times were analysed in 163 (SJL/J x CAST/Ei)F2 mice for Quantitative trait Loci that modify Scrapie disease. The onset of illness is shorter in SLJ/J mice then in CAST/Ei. F2 mice were analysed in a genome wide scan using 22shorter and 21 longer phenotypic variants. The results showed two regions of significants in the mouse genome. On chromosome 9 a region between D9Mit91 and D9Mit25 showed a significants with a peak LOD of 6.35. Moreover on Chromosome 11 a region between D11Mit219 and D11Mit212 showed a peak LOD of 5.60. The Chromosome 9 and 11 genes are designated as Pid2 and Pid3 respectively. With Pid2 showing a peak at D9Mit91 and Pid3 at D11Mit260

References

• Original: J:65122 Stephenson DA, et al., Quantitative trait loci affecting prion incubation time in mice. Genomics. 2000 Oct 1;69(1):47-53
• All: 1 reference(s)