Apoc1^tm1Lmh
Targeted Allele Detail

Summary

• Symbol: Apoc1^tm1Lmh
• Name: apolipoprotein C-I; targeted mutation 1, Louis M Havekes
• MGI ID: MGI:2157218
• Synonyms: apoc1-, apoCI-KO
• Gene: Apoc1 Location: Chr7:19423405-19426584 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoc1^tm1Lmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22858
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.7kb genomic fragment containing exons 1, 2 and part of 3 was replaced with a hygromycin selection cassette. Northern blot analysis revealed that the encoded transcript was not detectable in total liver RNA derived from homozygous mice. (J:22858)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoc1 Mutation: 11 strains or lines available

Notes

Homozygous mutant mice are viable and overtly normal.

References

• Original: J:22858 van Ree JH, et al., Increased response to cholesterol feeding in apolipoprotein C1-deficient mice. Biochem J. 1995 Feb 1;305(Pt 3):905-11
• All: 7 reference(s)