Apoh^tm1Krl
Targeted Allele Detail

Summary

• Symbol: Apoh^tm1Krl
• Name: apolipoprotein H; targeted mutation 1, Steven A Krilis
• MGI ID: MGI:2157224
• Synonyms: beta2GPI -
• Gene: Apoh Location: Chr11:108286123-108305222 bp, + strand Genetic Position: Chr11, 71.8 cM, cytoband D
• Alliance: Apoh^tm1Krl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.7kb genomic fragment containing part of exon 2 and exon 3 was replaced with a neomycin selection cassette. Northern blot analysis revealed that no encoded transcript was detectable in liver RNA derived from homozygous mice, and western blot analysis on plasma derived from homozygous mice demonstrated that no encoded protein was detectable. (J:68990)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoh Mutation: 23 strains or lines available

References

• Original: J:68990 Sheng Y, et al., Impaired thrombin generation in beta 2-glycoprotein I null mice. J Biol Chem. 2001 Apr 27;276(17):13817-21
• All: 5 reference(s)