C10bw2^{M. m. castaneus}
QTL Variant Detail

Summary

• QTL variant: C10bw2^{M. m. castaneus}
• Name: castaneus 10 week body weight 2; M. m. castaneus
• MGI ID: MGI:2157244
• QTL: C10bw2 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 20.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: M. m. castaneus

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased body weight in female animals compared to C57BL/6J. (J:64750)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

C10bw2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:64750

A total of 387 male and female mice used in a genome wide scan for Body Weight QTLs and were derived from (C57BL/6J x M.m. castaneus) F1 females backcrossed to M.m. castaneus. M.m. castaneus have body weight QTLs that are 60% lower then C57BL/6J mice at10 weeks of age.

Seven sex specific QTLs were mapped to mouse chromosomes. C10Bw1 mapped to mouse Chromosome 2 near D2Mit7 (LOD 10.7). C10Bw2 a female specific QTL mapped to chromosome 9 near D9Mit2 (LOD 3.6). C10Bw3 a male specific QTL mapped to chromosome11 near D11Mit67 (LOD 3.4). C10Bw4 a female specific QTL mapped to chromosome 13 near D13Mit26 (LOD 3.3). C10Bw5 a male specific QTL also mapped to chromosome 13 near D13Mit195 (LOD 3.7). C10Bw6 a female specific QTL mapped to the X chromosome near DXMit75 (LOD 4.3). C10Bw7 a male specific QTL mapped to Chromosome 12 near D12Mit4, but did not have a main effect and therefore was epistatic.

References

• Original: J:64750 Ishikawa A, et al., Detection of quantitative trait loci for body weight at 10 weeks from Philippine wild mice. Mamm Genome. 2000 Oct;11(10):824-30
• All: 1 reference(s)