Aldh2^tm1Kaw
Targeted Allele Detail

Summary

• Symbol: Aldh2^tm1Kaw
• Name: aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1, Toshihiro Kawamoto
• MGI ID: MGI:2157245
• Synonyms: ALDH2^-, mtALDH^-
• Gene: Aldh2 Location: Chr5:121704090-121731887 bp, - strand Genetic Position: Chr5, 61.86 cM, cytoband F-G1
• Alliance: Aldh2^tm1Kaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63498
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A termination codon and a neomycin selection cassette was inserted into exon 3. Western blot analysis on liver mitochondrial fractions derived from homozygous mice confirmed that the protein was not expressed at detectable levels. (J:63498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Aldh2 Mutation: 36 strains or lines available

References

• Original: J:63498 Kitagawa K, et al., Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 2000 Jul 7;476(3):306-11
• All: 62 reference(s)