Pbwg12^{M. m. castaneus}
QTL Variant Detail

Summary

• QTL variant: Pbwg12^{M. m. castaneus}
• Name: postnatal body weight growth 12; M. m. castaneus
• MGI ID: MGI:2157315
• QTL: Pbwg12 Location: Chr12:79040164-79040364 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 35.51 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: M. m. castaneus

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Pbwg12 is male-specific and participates in epsistatic interactive effects with Pbwg1.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:64750

A total of 387 male and female mice used in a genome wide scan for Body Weight QTLs and were derived from (C57BL/6J x M.m. castaneus) F1 females backcrossed to M.m. castaneus. M.m. castaneus have body weight QTLs that are 60% lower then C57BL/6J mice at10 weeks of age.

Seven sex specific QTLs were mapped to mouse chromosomes. C10Bw1 mapped to mouse Chromosome 2 near D2Mit7 (LOD 10.7). C10Bw2 a female specific QTL mapped to chromosome 9 near D9Mit2 (LOD 3.6). C10Bw3 a male specific QTL mapped to chromosome11 near D11Mit67 (LOD 3.4). C10Bw4 a female specific QTL mapped to chromosome 13 near D13Mit26 (LOD 3.3). C10Bw5 a male specific QTL also mapped to chromosome 13 near D13Mit195 (LOD 3.7). C10Bw6 a female specific QTL mapped to the X chromosome near DXMit75 (LOD 4.3). C10Bw7 a male specific QTL mapped to Chromosome 12 near D12Mit4, but did not have a main effect and therefore was epistatic.

J:88536

Linkage analysis was performed on 380 animals from a (C57BL/6J x M. m. castaneus)F1 x M. m. castaneus backcross to identify QTLs associated with postnatal growth. A total of 13 novel QTLs were mapped. Pbwg1-Pbwg7 affect the entire growth period whereas Pbw8 and Pbw9 affect the mid- and early growth phases. M. m. castaneus-derived alleles confer reduced growth at Pbwg1-Pbwg7. Pbwg10-Pbwg13 were detected in epistatic interactions involving other Pbwg QTLs.

Pbwg1 (postnatal body weight growth 1) mapped to35 cM on mouse Chromsome 2 near D2Mit324 (LOD=8.9). The 95% confidence interval of Pbwg1 spans 26 cM - 44 cM. Pbwg1 appears to have a stronger effect in females compared to males. This locus explains 10% of the phenotypic variance. Gcg is a candidate genemapping near Pbwg1. Pbwg11 maps to 87 cM (D2Mit48) on mouse Chromosome 2 and interacts epistatically with Pbwg4 (P=1.8 x 10-5).

A male-specific QTL named Pbwg2 mapped to 62 cM on mouse Chromosome 4 near D4Mit32 (LOD=2.9). The 95% confidence interval of Pbwg2 spans 39 cM - 86 cM. This locus explains 3.9% of the phenotypic variance.

Pbwg3 maps to 72 cM on mouse Chromosome 7 with D7Mit259 (LOD=3.0). The 95% confidence interval of Pbwg3 spans 40 cM - 104 cM. This locus explains 3.0% of the phenotypic variance. Candidate genes mapping near Pbwg3 are Tub, Ucp2, and Ucp3.

A female-specific QTL named Pbwg4 maps to 71 cM on mouse Chromosome 9 with D9Mit18 (LOD=3.7). The 95% confidence interval of Pbwg4 spans 46 cM - 96 cM. This locus explains 7.5% of the phenotypic variance.

Pbwg5 maps to 68 cM on mouse Chromosome 10 near D10Mit145 (LOD=3.4). The 95% confidence interval of Pbwg5 spans 42 cM - 94 cM. This locus explains 3.7% of the phenotypic variance. Igf1 is a candidate genes mapping near Pbwg5.

Pbwg9 mapsto 14 cM on mouse Chromosome 10 near D10Mit16 (LOD=3.8). The 95% confidence interval of Pbwg9 spans 0 cM - 36 cM. Pbw9 appears to have a stronger effect in females compared to males. This locus explains 4.5% of the phenotypic variance.

Pbwg6 maps to 53cMonmouse Chromosome 13 near D13Mit195 (LOD=4.9). The 95% confidence interval of Pbwg6 spans 34 cM - 72 cM. Pbwg6 appears to have a stronger effect in males compared to females. This locus explains 5.2% of the phenotypic variance.

A male-specific locus named Pbwg7 maps to 19 cM on mouse Chromosome X with marker DXMit75 (LOD=3.1). The 95% confidence interval of Pbwg7 spans 0 cM - 48 cM. This locus explains 6.9% of the phenotypic variance.

Pbwg10 maps to 2.8 cM (DXMit124) on mouse Chromosome X and interacts epistatically with Pbwg8 (P=2.6 x 10-6). The effect of the Pbwg10-Pbwg8 interaction is male-specific.

A male-specific locus named Pbwg8 maps to 32 cM on mouse Chromosome 6 near D6Mit29 (LOD=4.). The 95% confidence interval of Pbwg8 spans 14 cM - 50cM. This locus explains 12.1% of the phenotypic variance. Ghrhr is a candidate genes mapping near Pbwg8.

Pbwg12 maps to 34 cM (D12Mit4) on mouse Chromosome 12 and interacts epistatically with Pbwg1 (P=9.1 x 10-6). The effect of the Pbwg12-Pbwg1 interaction is male-specific.

Pbwg13 maps to 81 cM (D5Mit51) on mouse Chromosome 5 and interacts epistatically with Pbwg9 (P=2.5 x 10-6). The effect of the Pbwg12-Pbwg9 interaction is female-specific.

References

• Original: J:64750 Ishikawa A, et al., Detection of quantitative trait loci for body weight at 10 weeks from Philippine wild mice. Mamm Genome. 2000 Oct;11(10):824-30
• All: 2 reference(s)