Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Apmt1 and Apmt2 participate in epistatic interactions. Animals homozygous for FVB/NJ-derived alleles at Apmt1 and heterozygous at Apmt2 exhibit the highest incidence of mammary tumors.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:64663A genome wide scan using 69 markers was initiated to find loci responsible for tumor acceleration in mice. A total of 126 female mice from FVB/N females X (I/LnJ females X FVB/N-TgN(MMTVPyVT)634mul males) F1 males were informative. A region of mouse Chromosome 9 including D9Mit182 was correlated with an acceleration of tumorignensis. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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