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Apmt2I/LnJ
QTL Variant Detail
Summary
QTL variant: Apmt2I/LnJ
Name: accelerator of polyoma-induced mammary tumors 2; I/LnJ
MGI ID: MGI:2157319
QTL: Apmt2  Location: unknown  Genetic Position: Chr9, cM position of peak correlated region/allele: 53.48 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  I/LnJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased mammary tumor susceptibility compared to FVB/NJ. (J:64663)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Apmt1 and Apmt2 participate in epistatic interactions. Animals homozygous for FVB/NJ-derived alleles at Apmt1 and heterozygous at Apmt2 exhibit the highest incidence of mammary tumors.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:64663

A genome wide scan using 69 markers was initiated to find loci responsible for tumor acceleration in mice. A total of 126 female mice from FVB/N females X (I/LnJ females X FVB/N-TgN(MMTVPyVT)634mul males) F1 males were informative. A region of mouse Chromosome 9 including D9Mit182 was correlated with an acceleration of tumorignensis.

References
Original:  J:64663 Le Voyer T, et al., An epistatic interaction controls the latency of a transgene-induced mammary tumor. Mamm Genome. 2000 Oct;11(10):883-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory