Gulo^sfx
Spontaneous Allele Detail

Summary

• Symbol: Gulo^sfx
• Name: gulonolactone (L-) oxidase; spontaneous fracture
• MGI ID: MGI:2157331
• Gene: Gulo Location: Chr14:66224235-66246656 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Gulo^sfx page

Mutation origin

• Strain of Origin: BALB/cBy-Rasa3^scat

Mutation description

• Allele Type: Spontaneous
• Mutation: Deletion
• Gulo^sfx involves 1 genes/genome features (Gulo) View all
• The mutation in the sfx mouse is a deletion that includes the entire Gulo gene. (J:95128)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gulo Mutation: 28 strains or lines available

Notes

This spontaneous mutation appeared in a BALB/cBy-scat colony at The Jackson Laboratory. The scat and sfx mutations were separated from each other by backcrossing BALB/cBy-scat mice to BALB/cBy mice and observing F2 offspring for those that exhibited the sfx phenotype but not the scat phenotype.

References

• Original: J:66648 Beamer WG, et al., Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation. Bone. 2000 Nov;27(5):619-26
• All: 6 reference(s)