Hpic5^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Hpic5^DBA/2J
• Name: haloperidol-induced catelepsy 5; DBA/2J
• MGI ID: MGI:2157337
• QTL: Hpic5 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 16.84 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:61419

678 male animals from a (C57BL/6J x DBA/2J)F2 intercross were used to map catalepsy-related QTLs. Markers were typed at an average density of 20 cM. Hpic1, a QTL for haloperidol-induced catalepsy, mapped to 48 cM (QTL range spanning 25 cM - 55 cM) on chromosome 9 with a LOD score of 5.4 at D9Mit111. Candidate genes found at this locus include Drd2, Ncam, Acat1, Htr1b, Chrna5, Myo5a, and El1. A probable QTL for halperidol-induced catalepsy, Hpic5, mapped to 9 cM on Chromosome 1 with a LOD score exceeding the threshold of 3.5 at D9Mit188 and D9Mit90. Potential candidate genes in this region are Penk-rs and Gria4. The dilute coat color was found to segregate against the parental phenotype. Dilute DBA/2J animals have a haloperidol ED50 of 0.4 mg/kg and dilute C57BL/6J animals have a haloperidol ED50 of 4.0 mg/kg.

References

• Original: J:61419 Patel NV, et al., Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross. Behav Genet. 1999 Sep;29(5):303-10
• All: 1 reference(s)