Skts5^NIH/Ola
QTL Variant Detail

Summary

• QTL variant: Skts5^NIH/Ola
• Name: skin tumor susceptibility 5; NIH/Ola
• MGI ID: MGI:2157355
• QTL: Skts5 Location: Chr12:39148866-39149016 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 18.06 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NIH/Ola

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to skin tumorigenesis compared to M. spretus. (J:59049)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59049

Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH/Ola female x M. spretus male)F1 female mice mated back to NIH/Ola male mice. Using negative binomial regression analysis, significant linkage of Skts5 with D12Mit154 (lod 3.45) was observed on mouse Chromosome 12.

References

• Original: J:59049 Nagase H, et al., A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15032-7
• All: 2 reference(s)