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Obq6C57BL/6J
QTL Variant Detail
Summary
QTL variant: Obq6C57BL/6J
Name: obesity QTL 6; C57BL/6J
MGI ID: MGI:2157361
QTL: Obq6  Location: ChrX:50772375-70434751 bp  Genetic Position: ChrX, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57787

The authors investigated the inheritance of adiposity and related traits in the obese, diabetes-prone KK/H1Lt (KK) and the lean, normoglycemic C57BL/6J (B6) strains, their F1 hybrids, and a large intercross generation. Adiposity index (A1) was defined as the sum of four fat depot weights divided by body weight. A male-specific QTL affecting A1 was found between DXMit166 and DXMit25 on the X Chromosome. The lod score peak attained the value of 3.77 8 cM distal to DXMit166. This locus was designated as Obq6 and accounted for 11.7% of the phenotypic variance of A1 in males. Obq6 had a signifiant effect on gonadal fat % (lod = 4.1), inguinal fat % (lod = 2.8) and retroperitoneal fat % (lod = 3.6). There was no association between mesenteric fat and Obq6. A modified A1 was calculated excluding mesenteric fat % and this analysis revealed a lod peak score of 5.0 at 6 cM distal to DXMit166 and accounted for 15.7% of the phenotypic variability in males.

References
Original:  J:57787 Taylor BA, et al., Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain. Mamm Genome. 1999 Oct;10(10):963-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory