Obq6^KK/HlLt
QTL Variant Detail

Summary

• QTL variant: Obq6^KK/HlLt
• Name: obesity QTL 6; KK/HlLt
• MGI ID: MGI:2157362
• QTL: Obq6 Location: ChrX:50772375-70434751 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: KK/HlLt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity in male animals compared to C57BL/6J. (J:57787)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57787

The authors investigated the inheritance of adiposity and related traits in the obese, diabetes-prone KK/H1Lt (KK) and the lean, normoglycemic C57BL/6J (B6) strains, their F1 hybrids, and a large intercross generation. Adiposity index (A1) was defined as the sum of four fat depot weights divided by body weight. A male-specific QTL affecting A1 was found between DXMit166 and DXMit25 on the X Chromosome. The lod score peak attained the value of 3.77 8 cM distal to DXMit166. This locus was designated as Obq6 and accounted for 11.7% of the phenotypic variance of A1 in males. Obq6 had a signifiant effect on gonadal fat % (lod = 4.1), inguinal fat % (lod = 2.8) and retroperitoneal fat % (lod = 3.6). There was no association between mesenteric fat and Obq6. A modified A1 was calculated excluding mesenteric fat % and this analysis revealed a lod peak score of 5.0 at 6 cM distal to DXMit166 and accounted for 15.7% of the phenotypic variability in males.

References

• Original: J:57787 Taylor BA, et al., Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain. Mamm Genome. 1999 Oct;10(10):963-8
• All: 1 reference(s)