Pvcan2^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: Pvcan2^BALB/cByJ
• Name: protection against vaginal candidiasis 2; BALB/cByJ
• MGI ID: MGI:2157363
• QTL: Pvcan2 Location: Chr9:36943406-36943525 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 20.71 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57639

Forty (BALB/cByJ x C57BL/6ByJ)F1 x C57BL/6ByJ backcross animals were typed for 51 microsatellite markers to detect loci associated with protection against vaginal candidiasis. Parental inbred strain BALB/cByJ is protected from candidiasis after immunization and subsequent challenge with Candida albicans where as parental inbred strain C57BL/6ByJ is not protected. The trait appears to be dominantly inherited since (BALB/cByJ x C57BL/6ByJ)F1 animals exhibit protection similar to BALB/cByJ. QTLs were detected on mouse Chromosomes 8, 9, and 18. Pvcan1 maps to mouse Chromosome 8 with a LOD = 2.2 at D8Mit155 and D8Mit58 at approximately 1 cM - 2 cM. A candidate locus for Pvcan1 is the Fc receptor for IgE, Fcer2a. Pvcan2 maps to mouse Chromosome 9 with a LOD = 1.9 at D9Mit67 at approximately 17 cM. A candidate locus for Pvcan2 is Icam1. Pvcan3 maps to mouse Chromosome 18 with a LOD = 2.0 at D18Mit63 at approximately 16 cM. A candidate locus for Pvcan3 is Icam1-rs1.

References

• Original: J:57639 Mulero-Marchese RD, et al., Strain-dependent migration of lymphocytes to the vaginal mucosa after peripheral immunization. Immunogenetics. 1999 Oct;49(11-12):973-80
• All: 1 reference(s)