Il1a^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il1a^tm1Yiw
• Name: interleukin 1 alpha; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:2157371
• Synonyms: IL-1alpha-, IL-1alpha KO
• Gene: Il1a Location: Chr2:129141530-129151892 bp, - strand Genetic Position: Chr2, 62.9 cM, cytoband F
• Alliance: Il1a^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47429
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-PGK-hygromycin expression cassette replaced 1.5kb of sequence, including the region in exon 5 that encodes the amino terminal region of the mature protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429, J:92002)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1a Mutation: 30 strains or lines available

References

• Original: J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
• All: 173 reference(s)