Apobec1^tm1Rub
Targeted Allele Detail

Summary

• Symbol: Apobec1^tm1Rub
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; targeted mutation 1, Edward M Rubin
• MGI ID: MGI:2157378
• Synonyms: Apobec-, apobec-1^delta6
• Gene: Apobec1 Location: Chr6:122554751-122579403 bp, - strand Genetic Position: Chr6, 57.68 cM
• Alliance: Apobec1^tm1Rub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 6 was replaced with a neomycin selection cassette. These sequences include the majority of the coding sequences of the gene. RT-PCR analysis confirmed the absence of encoded transcript in various tissues of homozygous mice. (J:74021)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apobec1 Mutation: 28 strains or lines available

References

• Original: J:74021 Morrison JR, et al., Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7154-9
• All: 4 reference(s)