Bwtq4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bwtq4^C57BL/6J
• Name: body weight QTL 4; C57BL/6J
• MGI ID: MGI:2157385
• QTL: Bwtq4 Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 9, Ets1 (15 cM) showed differential expression between the restricted and unrestricted diets on the A/A^vy background and between A/a and A/A^vy animals on both therestricted and unrestricted diets. Diabesity QTLs mapping near Ets1 are Bwtq4 (8 cM) and Obq5 (19 cM). A candidate gene for diabesity QTL Dob2 (60 cM) is Cacna2d2 (60 cM). Cacna2d2 shows differential expression between the restricted and unrestricted diets on a A/a background.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53812

Genome scan was performed on animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with tail length and age-related body weight, and test concordance with QTLs mapped in a previous study. DBA/2J animals are heavier than C57BL/6J animals. Five out of 11 previously mapped QTLs were detected. QTLs for body weight at 3 weeks of age mapped to mouse Chromosome 4 from 40 cM - 60 cM (Bwtq2, LOD = 4.4 at 55 cM), mouse Chromosome 9 from 0 cM - 50 cM (Bwtq4, LOD = 8.3 at 8 cM), and mouse Chromosome 11 from 20 cM - 55 cM (Bwtq5, LOD = 9.5 at 27.8 cM). QTLs for body weight at 10 weeks of age mapped to mouse Chromosome 1 from 40 cM - 70 cM (Bwtq1, LOD = 8.8 at 54.3 cM), mouse Chromosome 6 from 0 cM - 29 cM (Bwtq3, LOD = 4.4 at 4 cM), and mouse Chromosome 15 from 25 cM - 50 cM (Bwtq6, LOD = 7.6 at 41.2 cM). A major QTL for tail length mapped to mouse Chromosome 1 from 40 cM - 70 cM (Tlln, LOD = 33 at 50 cM).

References

• Original: J:53812 Morris KH, et al., Quantitative trait loci for growth traits in C57BL/6J x DBA/2J mice. Mamm Genome. 1999 Mar;10(3):225-8
• All: 1 reference(s)