Bwtq5^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bwtq5^C57BL/6J
• Name: body weight QTL 5; C57BL/6J
• MGI ID: MGI:2157387
• QTL: Bwtq5 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A^vy background.

Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A^vy background. Sept8 shows differential expression between A/a and A/A^vy animals on the restricted diet.

Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A^vy animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A^vy animals on the restricted diet.

Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A^vy background while Grb2 shows differential expression between A/a and A/A^vy animals on the unrestricted diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53812

Genome scan was performed on animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with tail length and age-related body weight, and test concordance with QTLs mapped in a previous study. DBA/2J animals are heavier than C57BL/6J animals. Five out of 11 previously mapped QTLs were detected. QTLs for body weight at 3 weeks of age mapped to mouse Chromosome 4 from 40 cM - 60 cM (Bwtq2, LOD = 4.4 at 55 cM), mouse Chromosome 9 from 0 cM - 50 cM (Bwtq4, LOD = 8.3 at 8 cM), and mouse Chromosome 11 from 20 cM - 55 cM (Bwtq5, LOD = 9.5 at 27.8 cM). QTLs for body weight at 10 weeks of age mapped to mouse Chromosome 1 from 40 cM - 70 cM (Bwtq1, LOD = 8.8 at 54.3 cM), mouse Chromosome 6 from 0 cM - 29 cM (Bwtq3, LOD = 4.4 at 4 cM), and mouse Chromosome 15 from 25 cM - 50 cM (Bwtq6, LOD = 7.6 at 41.2 cM). A major QTL for tail length mapped to mouse Chromosome 1 from 40 cM - 70 cM (Tlln, LOD = 33 at 50 cM).

References

• Original: J:53812 Morris KH, et al., Quantitative trait loci for growth traits in C57BL/6J x DBA/2J mice. Mamm Genome. 1999 Mar;10(3):225-8
• All: 1 reference(s)