Skull12^LG/J
QTL Variant Detail

Summary

• QTL variant: Skull12^LG/J
• Name: skull morphology 12; LG/J
• MGI ID: MGI:2157392
• QTL: Skull12 Location: Chr9:37306197-37306370 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 20.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased size in skull characteristics compared to SM/J. (J:53484)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53484

76 polymorphic markers at an average spacing of 27.5 cM were screened in 535 F2 animals from a cross between inbred strains LG/J and SM/J to identify QTLs affecting skull morphology characteristics. The LG/J strain has a larger body size than the SM/J strain. A total of 26 skull morphology QTLs were identified. On mouse Chromosome 1, Skull1 maps to 46 cM - 68 cM with LOD=4.67 at D1Mit7 and Skull2 maps to 104 cM - 134 cM with LOD>3.03 at D1Mit14. On mouse Chromosome 2, Skull3 maps to 69 cM - 78 cM with LOD=9.32 at D2Mit17. On mouse Chromosome 3, Skull4 maps to 43 cM - 53 cM with LOD-12.05 at D3Mit22. On mouse Chromosome 4, Skull5 maps to 26 cM - 54 cM with LOD=6.41 and Skull6 maps to 66 cM - 84 cM with LOD>3.03 at D4Mit16. On mouse Chromosome 6, Skull7 maps to 4 cM - 66 cM with LOD=8.44 at D6Mit1 and Skull8 maps to 82 cM - 100 cM with LOD>3.03 at D6Nds5. On mouse Chromosome 7, Skull9 maps to 27 cM - 61 cM with LOD=17.41 at D7Nds1 and Skull10 maps to 61 cM - 105 cM with LOD>3.03 at D7Mit17. On mouse chromosome 8, Skull11 mapsto 31 cM-63 cM with LOD=3.83 at D8Mit8. On mouse Chromosome 9, Skull12 maps to 16 cM - 24 cM with LOD=5.32 at D9Mit2 and Skull13 maps to 48 cM - 74 cM with LOD>3.03 at D9Mit8. On mouse Chromosome 10, Skull14 maps to 59 cM - 71 cM withLOD=7.27 at D10Mit20. On mouse Chromosome 11, Skull15 maps to 23 cM - 55 cM with LOD=5.85 at D11Mit62 and Skull16 maps to 69 cM - 99 cM with LOD>3.03 at D11Mit14. On mouse Chromosome 12, Skull17 maps to 1 cM - 39 cM with LOD=10.33 at D12Mit37 and Skull18maps to 47 cM - 63 cM with LOD>3.03 at D12Mit6. On mouse Chromosome 13, Skull19 maps to 7 cM - 41 cM with LOD=2.95 at D13Mit1 and Skull20 maps to 7 cM - 97 cM with P<0.05 at D13Mit9. On mouse Chromosome 14, Skull21 maps to 28 cM - 56 cM with LOD-4.66 atD14Mit5. On mouse Chromosome 15, Skull22 maps to 47 cM - 57 cM with LOD=12.63 at D15Mit15. On mouse Chromosome 16, Skull23 maps to 30 cM - 44 cM with LOD-3.96 at D16Mit2. On mouse Chromosome 17, Skull 24 maps to 15 cM - 21 cM with LOD=4.35 at D17Mit46 andSkull25 maps to 21 cM - 57 cM with LOD>3.03 at D17Mit16. On mouse Chromosome 19, Skull26 maps to 15 cM - 21 cM with LOD=3.55 at D19Mit16.

References

• Original: J:53484 Leamy LJ, et al., Quantitative trait loci for early- and late-developing skull characters in mice: a test of the genetic independence model of morphological integration. Am Naturalist. 1999;153(2):201-214
• All: 1 reference(s)