Il1rn^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il1rn^tm1Yiw
• Name: interleukin 1 receptor antagonist; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:2157397
• Synonyms: IL-1Ra-, IL-1ra KO
• Gene: Il1rn Location: Chr2:24226872-24241503 bp, + strand Genetic Position: Chr2, 16.36 cM
• Alliance: Il1rn^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47429
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced all the coding regions for the secreted form of the protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rn Mutation: 23 strains or lines available

References

• Original: J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
• All: 50 reference(s)