Il1rn^tm1Dih
Targeted Allele Detail

Summary

• Symbol: Il1rn^tm1Dih
• Name: interleukin 1 receptor antagonist; targeted mutation 1, David Hirsh
• MGI ID: MGI:2157398
• Synonyms: IL-1ra-, rako
• Gene: Il1rn Location: Chr2:24226872-24241503 bp, + strand Genetic Position: Chr2, 16.36 cM
• Alliance: Il1rn^tm1Dih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36387
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon III disrupted the sequence encoding the secreted protein. Northern blot analysis of lung tissue collected after LPS injection did not detect transcript in homozygous mutant mice. (J:36387)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1rn Mutation: 23 strains or lines available

References

• Original: J:36387 Hirsch E, et al., Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13
• All: 23 reference(s)