Eae9^B10.S/DvTe
QTL Variant Detail

Summary

• QTL variant: Eae9^B10.S/DvTe
• Name: experimental allergic encephalomyelitis susceptibility 9; B10.S/DvTe
• MGI ID: MGI:2157436
• QTL: Eae9 Location: Chr9:49420298-63239852 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 35.6 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.S/DvTe

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Heterozygous animals exhibit shorter EAE disease duration. (J:49054)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49054

Authors isolated quantitative trait loci believed to be invloved with the disease frequency of experimental allergic encephalomyelitis (EAE). (SJL/J x B10.S/DvTe)F2; SJL/J (susceptible) and B10.S/DvTe (resistant) mice; were bred to create F2 progeny used in the analysis.

A genome wide scan of 291 affected and 390 unaffected animals indicated the presence a locus mapping to mouse Chromosome 9, between D9Mit22 and D9Mit105, named Eae9 by the authors.

References

• Original: J:49054 Butterfield RJ, et al., New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol. 1998 Aug 15;161(4):1860-7
• All: 1 reference(s)