Rapop2^STS/A
QTL Variant Detail

Summary

• QTL variant: Rapop2^STS/A
• Name: radiation-induced apoptosis 2; STS/A
• MGI ID: MGI:2157469
• QTL: Rapop2 Location: Chr9:93417989-93418183 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to radiation-induced apoptosis in colon crypt cells compared to BALB/cHeA. (J:47265)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30582

Susceptibility to cell death (apoptosis) varies significantly between the inbred strains BALB/cHeA (resistant) and STS/A (susceptible), therefore recombinant congenic strains derived from these inbreds will be informative for identifying chromosome regions contributing to the cell death phenotype. In F2 crosses involving recombinant congenic strain CcS-8 with progenitor inbred BALB/cHeA and CcS-8 with CcS-10 a highly significant association was found in the region of mouse Chromosome 9 including the D9Mit59, D9Mit42 and D9Mit2 markers. The symbol assigned for the phenotype is Rapop2 and can be considered a quantitative trait.

J:47265

Authors analyzed linkage of radiation-induced apoptosis susceptibility in colon using 180 (CcS-7 x BALB/c)F2 animals. The CcS-7 strain is more susceptible to colonic apoptosis (but less susceptible to thymic apoptosis) than the BALB/c strain. Linkage of the phenotype to marker D9Mit239 on mouse Chromosome 9 was found. This marker is included in the region defining the Rapop2 QTL responsible for apoptosis susceptibility in the thymus. It is not clear whether the colonic susceptibility gene is the same or near the thymic susceptibility gene.

References

• Original: J:47265 Mori N, et al., Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on chromosomes 9 and 16. Mamm Genome. 1998 May;9(5):377-80
• All: 2 reference(s)