Char1^C3H/He
QTL Variant Detail

Summary

• QTL variant: Char1^C3H/He
• Name: P. chabaudi malaria resistance QTL 1; C3H/He
• MGI ID: MGI:2157479
• QTL: Char1 Location: Chr9:98680321-98680445 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 51.41 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/He

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44414

Inbred strains SJL and C3H/He are susceptible to Plasmodium chabaudi induced malaria where as C57BL/6 mice are resistant. Two crosses involving SJL, C3H/He and C57BL/6 revealed that quantitative trait locus controlling the response to Plasmodium chabaudi was associated significantly with mouse Chromosome 9. This locus, designated as Char1 has a maximum LOD score of 11.5 at D9Mit35.

1.19.2016 Curator Note: Authors refer to the QTL mapping to Chr 9 in both crosses as Char1. However, because two differing crosses were used we consider each a separate mapping experiment and have named the QTL identified on Chr 9 in the (SJL x C57BL/6)F2 cross as Char10, P. chabaudi malaria resistance QTL 10. Char1 remains associated with the (C3H/He x C57BL/6)F2 cross.

Char10 peaks at marker D9Mit12 on Chr 9, also with a LOD score of 11.5.

A second QTL was also identified in the (C3H/H x C57BL/6)F2 cross mapping to Chr 8.

The locus was labeled Char2, P. chabaudi malaria resistance QTL 2, peaking at marker D8Mit33 with a LOD score of 5.95.

J:72455

Genome scan was performed on 141 (C3H/He x C57BL/6)F2 female animals to identify QTLs associated with malaria resistance. Parental strain C3H/He is susceptible to infection by Plasmodium chabaudi adami whereas parental strain C57BL/6 is resistant. Significant linkage was detected on mouse Chromosome 17 near the H2 locus. This QTL was named Char3 and is closely linked to D17Mit21 at 18.67 cM (LOD=5.0). The C57BL/6-derived allele at Char3 confers decreased parasite load at day 11 post-infection with a dominant mode of inheritance.

Previously mapped QTLs Char1 (D9Mit182) and Char2 (D8Mit33) were also detected in this study.

References

• Original: J:44414 Foote SJ, et al., Mouse loci for malaria-induced mortality and the control of parasitaemia [letter]. Nat Genet. 1997 Dec;17(4):380-1
• All: 2 reference(s)