Rapop7^C3H/Kam
QTL Variant Detail

Summary

• QTL variant: Rapop7^C3H/Kam
• Name: radiation-induced apoptosis 6; C3H/Kam
• MGI ID: MGI:2157485
• QTL: Rapop7 Location: Chr9:36736243-49420511 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: C3H/Kam

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Heterozygous animals exhibit increased radiation-induced apoptosis in thymocytes. (J:44257)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44257

In a genome wide scan a quantitative trait locus (QTL), Rapop2, controlling radiation induced thymocyte apoptosis in (C57BL/6J x C3Hf/Kam)F2 mice was associated with loci on mouse Chromosome 9. A maximum LRS (likelihood ratio statistic) of 15.4 was calculated to show a significant association with Rapop5 and the Chromosome 9 region flanked by D9Mit224 and D9Mit22.

04.13.2015 Curators Note: Because Rapop2 was originally mapped in J:24435 in 1995 using recombinant congenic strain CcS-7 with progenitor inbred BALB/cHeA, which differs from the cross used here, we consider the current mapping study a separate mapping experiment and have named this QTL Rapop7.

References

• Original: J:44257 Weil MM, et al., Identification of quantitative trait loci controlling levels of radiation-induced thymocyte apoptosis in mice. Genomics. 1997 Nov 1;45(3):626-8
• All: 1 reference(s)