Twist1^Pde
Chemically induced Allele Detail

Summary

• Symbol: Twist1^Pde
• Name: twist basic helix-loop-helix transcription factor 1; polydactyly EMS
• MGI ID: MGI:2157489
• Synonyms: Pde, Twist^J
• Gene: Twist1 Location: Chr12:34007670-34009828 bp, + strand Genetic Position: Chr12, 14.81 cM, cytoband B-C1
• Alliance: Twist1^Pde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60747
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Chemically induced (other) (Not Applicable)
• Mutation: Undefined
• Mutation details: A complementation test confirmed that Pde is an allele of Twist. Sequencing the full-length cDNA and several hundred basepairs of genomic DNA upstream of the coding region failed to reveal a mutation, suggesting that the lesion may be in a regulatory element of the gene. (J:69450)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Twist1 Mutation: 18 strains or lines available

References

• Original: J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
• All: 2 reference(s)