Fbn2^fp-3J
Chemically induced Allele Detail

Summary

• Symbol: Fbn2^fp-3J
• Name: fibrillin 2; fused phalanges 3 Jackson
• MGI ID: MGI:2157491
• Synonyms: Fbn2^fp-3J, Fbn2^fp-sne, sne
• Gene: Fbn2 Location: Chr18:58141689-58343200 bp, - strand Genetic Position: Chr18, 32.15 cM, cytoband D-E1
• Alliance: Fbn2^fp-3J page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60747
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutations: Intragenic deletion, Transposon insertion
• Mutation details: The 3' end of a LINE element, including an approximately 120-bp poly(A) tail, 657 bp of 3'UTR, and 61 amino acids from the 3' end of ORF2, replaced a 672 bp segment of the gene including 465 bp of the 3' end of intron 57, exon 58 in its entirety, and 81 bp of the 5' end of intron 59. (J:69450)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbn2 Mutation: 143 strains or lines available

Notes

v6.4 ES cells were heavily mutagenized with ethylmethanesulphonate (EMS).

References

• Original: J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
• All: 2 reference(s)