Eae18^ABH
QTL Variant Detail

Summary

• QTL variant: Eae18^ABH
• Name: experimental allergic encephalomyelitis susceptibility 18; ABH
• MGI ID: MGI:2157549
• QTL: Eae18 Location: Chr18:57590559-82604728 bp Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: ABH

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE susceptibility compared to NOD.
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29171

The segregation of genes that may contribute to the susceptibility of experimental allergic encephalomyelitis in mice was analyzed in (ABH x NOD)F1 x NOD backcross mice. In a genome wide scan including all autosomes and the X-Chromosome a total of 100 microsatellites were examined.

Significant association of Eae18 with mouse Chromosome 18 was indicated and included a region defined by the proximal locus D18Mit19 and the distal locus D18Nds1.

References

• Original: J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
• All: 1 reference(s)