Dob3^AKR/J
QTL Variant Detail

Summary

• QTL variant: Dob3^AKR/J
• Name: dietary obesity 3; AKR/J
• MGI ID: MGI:2157553
• QTL: Dob3 Location: unknown Genetic Position: Chr15, cM position of peak correlated region/allele: 15.74 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity compared to SWR/J. (J:20700)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele is consistent with dominant or additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20700

Analysis of 189 (AKR x SWR/J) F2 mice indicates that a QTL (Dob3) affecting dietary obesity in AKR/J is located on Chromosome 15 between D15Nds2 and D15Mit22 with a peak LOD score of 3.93. The 189 animals used for statistical analysis represent the 10%tails of the phenotype distribution for the total F2 population (931 animals) and may not accurately represent the percentage of variance controlled by this locus. F1 X SWR/J backcross analysis confirmed the F2 mapping.

References

• Original: J:20700 West DB, et al., Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest. 1994 Oct;94(4):1410-6
• All: 1 reference(s)