Nr4a2^tm1Tpe
Targeted Allele Detail

Summary

• Symbol: Nr4a2^tm1Tpe
• Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Thomas Perlmann
• MGI ID: MGI:2157566
• Synonyms: Nurr1-
• Gene: Nr4a2 Location: Chr2:56996842-57014015 bp, - strand Genetic Position: Chr2, 31.66 cM
• Alliance: Nr4a2^tm1Tpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39661
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a neomycin resistance cassette replaces the sequence encoding the N terminal transactivation and DNA binding domains (exons 2,3 and part of 4). In situ hybridization detected no transcript from this gene in homozygous mutant mice. (J:39661)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr4a2 Mutation: 44 strains or lines available

References

• Original: J:39661 Zetterstrom RH, et al., Dopamine neuron agenesis in Nurr1-deficient mice [see comments]. Science. 1997 Apr 11;276(5310):248-50
• All: 20 reference(s)