Tlf^NOD/Smrf
QTL Variant Detail

Summary

• QTL variant: Tlf^NOD/Smrf
• Name: T lymphocyte fraction; NOD/Smrf
• MGI ID: MGI:2157567
• QTL: Tlf Location: Chr9:34837748-37306370 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 52.24 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/Smrf

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased CD4+ levels in male animals compared to NOD/Lt. (J:49676)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30526

The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.

J:49676

The author refines the mapping of a region which governs the unusually high fraction of circulating T lymphocytes in the nonobese diabetic (NOD) mice. Linkage analysis of (NON/Lt x NOD/Smrf)F1 x NOD/Smrf, and (NOD/Smrf x NON/Lt)F1 x NOD/Smrf progeny, and F2 animals from F1 crosses indicates that the phenotype is associated with two regions of mouse Chromosme 9. One region, Tlf, was placed between D9Mit66 (15 cM) and D9Mit2 (17 cM). The second region, Tlf2, was placed distal near D9Mit71 (29 cM).

References

• Original: J:49676 Pearce RB, Fine-mapping of the mouse T lymphocyte fraction (Tlf) locus on chromosome 9: association with autoimmune diabetes. Autoimmunity. 1998;28(1):31-45
• All: 2 reference(s)