Tlf2^NOD/Smrf
QTL Variant Detail

Summary

• QTL variant: Tlf2^NOD/Smrf
• Name: T lymphocyte fraction 2; NOD/Smrf
• MGI ID: MGI:2157569
• QTL: Tlf2 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 27.07 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/Smrf

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased CD8+ levels in female animals compared to NOD/Lt. (J:49676)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49676

The author refines the mapping of a region which governs the unusually high fraction of circulating T lymphocytes in the nonobese diabetic (NOD) mice. Linkage analysis of (NON/Lt x NOD/Smrf)F1 x NOD/Smrf, and (NOD/Smrf x NON/Lt)F1 x NOD/Smrf progeny, and F2 animals from F1 crosses indicates that the phenotype is associated with two regions of mouse Chromosme 9. One region, Tlf, was placed between D9Mit66 (15 cM) and D9Mit2 (17 cM). The second region, Tlf2, was placed distal near D9Mit71 (29 cM).

References

• Original: J:49676 Pearce RB, Fine-mapping of the mouse T lymphocyte fraction (Tlf) locus on chromosome 9: association with autoimmune diabetes. Autoimmunity. 1998;28(1):31-45
• All: 1 reference(s)