Atp1b2^tm1Msch
Targeted Allele Detail

Summary

• Symbol: Atp1b2^tm1Msch
• Name: ATPase, Na+/K+ transporting, beta 2 polypeptide; targeted mutation 1, Melitta Schachner
• MGI ID: MGI:2157776
• Synonyms: AMOG⁰, AMOG/beta 2-deficient
• Gene: Atp1b2 Location: Chr11:69490562-69496768 bp, - strand Genetic Position: Chr11, 42.86 cM
• Alliance: Atp1b2^tm1Msch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21121
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the first coding exon. Western blot analysis on crude membrane preparations of brain derived from homozygous mice demonstrated that no encoded protein was detectable. (J:21121)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp1b2 Mutation: 23 strains or lines available

References

• Original: J:21121 Magyar JP, et al., Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase. J Cell Biol. 1994 Nov;127(3):835-45
• All: 5 reference(s)