Otx2^tm3(otd)Asim
Targeted Allele Detail

Summary

• Symbol: Otx2^tm3(otd)Asim
• Name: orthodenticle homeobox 2; targeted mutation 3, Antonio Simeone
• MGI ID: MGI:2157778
• Synonyms: otd²
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm3(otd)Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72726
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A Drosophila orthodenticle cDNA including 56 bp of the 5' UTR, the entire coding region and 450 bp of the 3' UTR was fused to the endogenous 5'UTR lacking 213 bp upstream of the start codon. A neomycin selection cassette followed the inserted cDNA. (J:72726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:72726 Acampora D, et al., OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development. 2001 Dec;128(23):4801-13
• All: 1 reference(s)