Otx2^{tm5(OTX2)Asim}
Targeted Allele Detail

Summary

• Symbol: Otx2^{tm5(OTX2)Asim}
• Name: orthodenticle homeobox 2; targeted mutation 5, Antonio Simeone
• MGI ID: MGI:2157780
• Synonyms: Otx2^2c, Otx2^c
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^{tm5(OTX2)Asim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72726
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A human OTX2 cDNA coding region was fused to the start and stop codons of the endogenous gene. A neomycin selection cassette followed the inserted cDNA. This allele is used as a control for the Otx2^tm4(otd)Asim allele. (J:72726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:72726 Acampora D, et al., OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development. 2001 Dec;128(23):4801-13
• All: 1 reference(s)