Il1b^tm1Lvp
Targeted Allele Detail

Summary

• Symbol: Il1b^tm1Lvp
• Name: interleukin 1 beta; targeted mutation 1, Lex H T Van der Ploeg
• MGI ID: MGI:2157795
• Synonyms: IL-1beta-, IL-1beta^-
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^tm1Lvp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27234
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the first six exons. Northern blot analysis of liver tissue taken three hours after LPS injection did not detect mRNA in sensitized homozygous mutant mice. (J:27234)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Il1b^tm1Lvp/Il1b^tm1Lvp	129S7/SvEvBrd-Il1b^tm1Lvp
hm2	Il1b^tm1Lvp/Il1b^tm1Lvp	involves: 129S7/SvEvBrd
hm3	Il1b^tm1Lvp/Il1b^tm1Lvp	involves: 129S7/SvEvBrd * C57BL/6
hm4	Il1b^tm1Lvp/Il1b^tm1Lvp	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * RIIIS

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4
show or hide all annotated terms
cardiovascular system		√		√
abnormal tumor vascularization		√
abnormal blood-brain barrier function				√
hematopoietic system		√	√
abnormal lymphocyte physiology			√
abnormal macrophage physiology		√
homeostasis/metabolism		√	√	√
decreased circulating interleukin-1 beta level			√
impaired febrile response			√
decreased susceptibility to injury		√		√
immune system	N	√	√
immune system phenotype	N
abnormal lymphocyte physiology			√
abnormal macrophage physiology		√
decreased circulating interleukin-1 beta level			√
decreased interferon-gamma secretion			√
decreased interleukin-1 beta secretion		√
decreased interleukin-2 secretion			√
decreased interleukin-4 secretion			√
abnormal interleukin-6 secretion			√
decreased tumor necrosis factor secretion		√
decreased susceptibility to experimental autoimmune myasthenia gravis			√
decreased inflammatory response			√
decreased acute inflammation			√
increased susceptibility to bacterial infection induced morbidity/mortality		√
decreased susceptibility to viral infection		√
decreased susceptibility to Togaviridae infection		√
decreased susceptibility to Togaviridae infection induced morbidity/mortality		√
mortality/aging		√	√
increased susceptibility to bacterial infection induced morbidity/mortality		√
decreased susceptibility to Togaviridae infection induced morbidity/mortality		√
decreased susceptibility to induced morbidity/mortality		√	√
neoplasm		√
abnormal tumor vascularization		√
decreased metastatic potential		√
decreased tumor growth/size		√
nervous system				√
abnormal blood-brain barrier function				√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 25 strains or lines available

References

• Original: J:27234 Zheng H, et al., Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity. 1995 Jul;3(1):9-19
• All: 40 reference(s)