Ptger3^tm1Cof
Targeted Allele Detail

Summary

• Symbol: Ptger3^tm1Cof
• Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Thomas M Coffman
• MGI ID: MGI:2157796
• Synonyms: EP3-
• Gene: Ptger3 Location: Chr3:157272459-157350392 bp, + strand Genetic Position: Chr3, 81.32 cM
• Alliance: Ptger3^tm1Cof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52323
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette is inserted into exon 1. Exon 1 contains the the 5' untranslated sequence and a large portion of the coding region that extends through the sixth transmembrane domain. Northern analysis in RNA prepared from kidneys failed to detect a trasncript. (J:52323)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger3 Mutation: 19 strains or lines available

References

• Original: J:52323 Fleming EF, et al., Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Am J Physiol. 1998 Dec;275(6 Pt 2):F955-61
• All: 16 reference(s)