Bsc1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bsc1^C57BL/6J
• Name: brain size control 1; C57BL/6J
• MGI ID: MGI:2157859
• QTL: Bsc1 Location: Chr10:75516969-75517096 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 38.56 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased brain weight and striatal volume compared to A/J. (J:69683)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69683

Five different inbred strains were used in mapping loci influencing brain weight, striatal volume, striatal neuron-packing density, and striatal neuron number. Two QTLs, Bsc1(for striatal volume; LRS=17.5) and Stnn (for striatal neuron number; LRS = 15) mapped to mouse Chromosome 10 (in association with D10Mit186 at 29 cM) and Chromosome 19 (in association with D19Mit123 at 51 cM), respectively. Bsc1 and Stnn do not interact in controlling striatal volume or neuron number. Strains were chosen for phenotypic variance in the traits studied. Variation in brain weights for the different strains is as follows: RI strain BXD5 and inbred strain BALB/cJ represent high brain weights; C57BL/6J represents a mid brain weight; A/J and DBA/2J represent low brain weight. Striatal weights are significantly higher in BXD5 and BALB/cJ compared to A/J, C57BL/6J, and DBA/2J. Striatal neuron-packing density is greater in A/J and DBA/2J compared to C57BL/6J, BALB/cJ, and BXD5. Striatal neuron number did not vary significantly among the 5 strains.

References

• Original: J:69683 Rosen GD, et al., Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number. BMC Neurosci. 2001;2(1):5
• All: 1 reference(s)